matricin

Matricin is a natural product described as a sesquiterpene lactone that has been reported in certain members of the Asteraceae family, most notably Arnica montana (greater arnica) and Symphytum officinale (comfrey). In phytochemical literature, matricin appears as one of the resin or essential oil constituents of these plants and is sometimes cited as a precursor to other lactones that contribute to anti-inflammatory activity. The compound is lipophilic and has limited water solubility, which can affect its behavior in biological systems.

Biological activity and uses in herbal products are modestly documented. Laboratory studies have suggested anti-inflammatory potential, but matricin is generally considered less active than other related sesquiterpene lactones such as helenalin. In traditional herbal preparations, matricin-rich extracts have been used topically for bruises, sprains, and muscle pains; however, modern clinical evidence for efficacy is limited and varies by preparation and formulation.

Occurrence and quality control: Matricin content is reported as a marker in the chemical profiling of Arnica and comfrey extracts. Because Arnica products often contain other bioactive sesquiterpene lactones with irritant properties, formulations are typically standardized to specific lactone profiles rather than relying on matricin alone.

Safety and cautions: Comfrey and Arnica species contain constituents that can pose safety concerns, particularly if ingested or used on broken skin. While matricin itself is not the primary toxic agent, products containing high levels of arnica or comfrey should be used with caution and in accordance with regulatory guidance. See also Arnica montana, Symphytum officinale, sesquiterpene lactones, helenalin.