luteolin8Cglucoside

Luteolin 8-C-glucoside, also known as orientin, is a flavonoid glycoside found in various plants. It belongs to the class of flavonoids, which are secondary metabolites known for their antioxidant, anti-inflammatory, and potential health-promoting properties. Structurally, luteolin 8-C-glucoside consists of a luteolin aglycone (a flavone) linked to a glucose molecule via a carbon-carbon bond at the 8-position of the flavonoid skeleton.

This compound is commonly detected in foods such as whole grains, vegetables, herbs, and teas. Notable sources include oats, barley, celery, parsley, and some medicinal plants like *Artemisia* species. Due to its glycosylated form, luteolin 8-C-glucoside exhibits enhanced solubility in water compared to its aglycone counterpart, luteolin.

Research suggests that luteolin 8-C-glucoside may contribute to various biological activities. Studies indicate its potential role in modulating oxidative stress, reducing inflammation, and exhibiting neuroprotective effects. It has also been investigated for its possible anticancer properties, though further research is needed to confirm its efficacy in humans. The compound is generally considered safe, as it occurs naturally in dietary sources, but its effects at high concentrations or in specific populations require further study.

Pharmacologically, luteolin 8-C-glucoside is thought to interact with multiple molecular targets, including enzymes, receptors, and signaling pathways. Its bioavailability is influenced by factors such as gut microbiota metabolism and intestinal absorption, which may affect its overall physiological impact. Due to its presence in traditional diets, it has been a subject of interest in both nutritional and medicinal research.