lipidreplenishing
Lipidreplenishing is a term used in dermatology and cosmetic science to describe strategies and products designed to replenish the lipids in the stratum corneum, the skin's outermost barrier. The skin barrier relies on a lipid matrix dominated by ceramides, cholesterol, and free fatty acids. When this lipid content is reduced or imbalanced due to aging, environmental stress, or skin conditions such as xerosis and atopic dermatitis, barrier function can weaken, leading to dry, sensitive skin and increased water loss.
Lipidreplenishing products aim to restore the natural lipid composition and lamellar structure. Common ingredients include ceramides,
Mechanism: applied lipids integrate into the stratum corneum, helping rebuild the intercellular lipid layers, reduce transepidermal
Safety and regulation: products vary; ceramide- and lipid-rich moisturizers are generally well tolerated, though fragrance or
Evidence: randomized trials and meta-analyses indicate improvements in barrier function and symptom relief with ceramide-containing and