korkeaannoksinen

Korkeaannoksinen is a Finnish adjective meaning "high-dose" or "high-dosage," used to describe substances, exposures or interventions that involve quantities above typical or standard levels. The word derives from korkea ("high") and annos ("dose"), and is commonly applied in contexts such as pharmacology, toxicology, radiation, and environmental health.

In medicine and pharmacology, korkeaannoksinen refers to drug regimens or therapeutic exposures that exceed usual dosing ranges, whether for short-term intensified treatment or as an unintended overdose. The designation highlights altered risk–benefit considerations, increased potential for adverse effects, and the need for monitoring of therapeutic levels and organ function. In toxicology, it denotes exposure levels likely to produce toxic or lethal outcomes, with assessments based on metrics such as milligrams per kilogram (mg/kg) or concentration and duration of exposure.

Korkeaannoksinen is also used in radiation protection to describe high-dose radiation exposure, often quantified in grays (Gy), which can lead to deterministic effects and requires specific safety measures. Occupational, environmental and regulatory frameworks often define threshold values and control measures for korkeaannoksinen exposures to protect health.

Use of the term is descriptive rather than prescriptive; clinical decision-making about high-dose interventions involves specialist judgment, individualized assessment and adherence to professional guidelines and legal regulations. Common antonyms include matalaannoksinen (low-dose) and normaalannoksinen (standard-dose).