hydroxycitrate
Hydroxycitrate refers to the salts and esters of hydroxycitric acid (HCA), a naturally occurring compound most notably found in Garcinia cambogia and other Garcinia species. The name is typically used for the deprotonated form present in dietary supplements, such as calcium hydroxycitrate. HCA is a derivative of citric acid and is used in research and commercial products marketed for weight management.
Biochemical action and mechanism: In biochemical studies, hydroxycitrate inhibits ATP citrate lyase (ACLY), an enzyme that
Clinical use and evidence: HCA-containing products are marketed as weight-management supplements. Randomized trials have produced mixed
Safety, regulation, and cautions: HCA is not approved as a drug for obesity or metabolic disease. Safety
Source notes: In nature, HCA occurs in free form and as salts or esters; Garcinia cambogia is