hydroxyalkynes
Hydroxyalkynes are organic compounds that contain both a hydroxyl group (-OH) and a carbon–carbon triple bond (alkyne) within the same molecule. They are commonly referred to as alkynyl alcohols, with propargyl alcohol (HO-CH2-C≡CH) being the simplest example.
Structure and scope: Hydroxyalkynes can be terminal or internal. In propargyl alcohols the hydroxyl is on the
Preparation: The most common preparation route is the nucleophilic addition of a metal acetylide to an aldehyde
Reactivity and applications: The hydroxyl group provides a handle for further functionalization, such as ester or
Notes: Terminal hydroxyalkynes can be relatively acidic at the terminal hydrogen and may be sensitive to bases