filagryny
Filaggrin proteins, commonly referred to as filaggryns in some languages, are a family of keratinocyte proteins that contribute to the formation and maintenance of the skin’s outer barrier. They are encoded by the FLG gene in humans. Filaggrin is produced as profilaggrin, a large precursor stored in keratohyalin granules of differentiating epidermal cells.
During terminal differentiation, profilaggrin is dephosphorylated and proteolytically processed into multiple filaggrin monomers that bind and
Filaggrin breakdown products contribute to natural moisturizing factors (NMFs), such as urocanic acid and pyrrolidone carboxylic
Expression is highest in the epidermis, especially the stratum granulosum, and is regulated by calcium signaling
Filaggrin deficiency is a well-established risk factor for barrier disorders, including ichthyosis vulgaris and atopic dermatitis,