endotelialiska

Endotelialiska refers to the process by which a surface becomes lined with endothelial cells, the cells that form the inner lining of blood vessels. Endothelialization occurs naturally during embryonic development as the vascular system forms, and it also takes place during wound healing and tissue remodeling in adults. In medical and biomaterials contexts, endotelialiska describes the deliberate or assisted formation of an endothelial layer on implants, grafts, or scaffolds to promote biocompatibility and reduce thrombosis.

Mechanisms involve endothelial cells migrating, proliferating, and organizing to create a continuous monolayer. They establish cell–cell junctions and a basement membrane, and their alignment can be influenced by shear stress from blood flow. Regulatory signals include vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), and inflammatory cues, which together govern attachment, proliferation, and maturation of the endothelium.

Promotion strategies in tissue engineering and surgery include pre-seeding scaffolds with endothelial cells, modifying surface chemistry or topography to enhance attachment, delivering pro-angiogenic factors, and using decellularized matrices that preserve native endothelial cues. The goal is to achieve rapid and stable endothelialization to improve graft patency and integration.

Applications encompass vascular grafts and stents, tissue-engineered blood vessels, and wound healing contexts where a functional endothelium helps prevent thrombosis and supports vascular remodeling. Challenges include achieving uniform, durable coverage in vivo and maintaining endothelial phenotype under mechanical and inflammatory stresses. Related concepts include endothelium, angiogenesis, and vasculogenesis.