endometriallike

Endometriallike is a descriptive term used in histology and pathology to indicate that a tissue segment resembles the endometrium, the mucous lining of the uterus. The description typically applies to glands and stroma that mirror endometrial epithelium and supporting tissue in morphology and, often, in molecular markers.

In clinical pathology, endometriallike features are most commonly discussed in diseases involving Müllerian-type tissues outside the uterine cavity. For example, endometriosis may present with ectopic implants containing endometrial-type glands and stroma that can respond to ovarian hormones and exhibit cycle-dependent changes. The term can also describe areas within tumors that resemble endometrial tissue, such as endometrioid-type neoplasms where the architecture mimics endometrial morphology.

Immunohistochemistry supports the assessment of endometriallike tissue. Endometrial-like stroma often expresses CD10 and hormone receptors such as estrogen and progesterone receptors. The epithelial component may express cytokeratins (such as CK7) and PAX8, reflecting Müllerian origin. The degree of menstrual-cycle–related changes and the proliferation index can vary depending on tissue context and hormonal milieu.

Interpretation of the term is mainly diagnostic. Labeling tissue as endometriallike helps distinguish it from non-Müllerian tissues or other adenocarcinomas and may inform expectations about hormonal responsiveness and behavior within the appropriate clinical setting. The descriptor should be integrated with overall morphology and patient context rather than used in isolation.