aromatázenzimgátlók

Aromatázgátlók is the Hungarian term for aromatase inhibitors. Aromatase is an enzyme that catalyzes the conversion of androgens into estrogens. Aromatase inhibitors work by blocking the action of this enzyme, thereby reducing the production of estrogen in the body.

These drugs are primarily used in the treatment of hormone-receptor-positive breast cancer in postmenopausal women. In such cancers, estrogen can promote tumor growth. By lowering estrogen levels, aromatase inhibitors can help to slow or stop the progression of the disease. They are also used in fertility treatments to stimulate ovulation.

There are different types of aromatase inhibitors, broadly categorized into steroidal and non-steroidal compounds. Steroidal inhibitors, such as exemestane, irreversibly bind to the aromatase enzyme. Non-steroidal inhibitors, like anastrozole and letrozole, reversibly bind to the enzyme. The choice of inhibitor often depends on individual patient factors and treatment protocols.

Common side effects associated with aromatase inhibitors can include hot flashes, joint pain (arthralgia), muscle aches, fatigue, and an increased risk of osteoporosis due to bone loss. Regular monitoring for bone density is often recommended for patients on long-term therapy. Other potential side effects may include vaginal dryness, mood changes, and headaches. The benefits of aromatase inhibitors in treating breast cancer generally outweigh the risks for eligible patients.