amikasin
Amikacin, sometimes spelled amikasin in some sources, is an aminoglycoside antibiotic developed as a semi-synthetic derivative of kanamycin A. It is produced by Streptomyces kanamyceticus and is used to treat various severe bacterial infections.
Mechanism of action: Amikacin binds irreversibly to the 30S ribosomal subunit, causing misreading of messenger RNA
Spectrum and uses: It has broad activity against many Gram-negative organisms, including Pseudomonas aeruginosa and many
Administration and pharmacokinetics: Amikacin is given parenterally (intravenous or intramuscular). It is poorly absorbed from the
Adverse effects and safety: The main toxicities are nephrotoxicity and ototoxicity (cochlear and vestibular), which can
Resistance: Bacteria may develop resistance via aminoglycoside-modifying enzymes or 16S rRNA methyltransferases, reducing amikacin activity.