ZDHHCjäsenet

ZDHHCjäsenet refers to a family of enzymes known as palmitoyltransferases. These enzymes are characterized by a ZDHHC domain, a conserved cysteine-rich region that is essential for their catalytic activity. This domain plays a crucial role in the process of S-palmitoylation, a post-translational modification where a fatty acid, palmitate, is covalently attached to a cysteine residue of a target protein. This modification can occur on both soluble and membrane proteins.

The primary function of ZDHHCjäsenet is to mediate the reversible attachment of palmitate to specific proteins. This lipidation process significantly influences the localization, stability, trafficking, and protein-protein interactions of the modified proteins. It can anchor proteins to cellular membranes, promote their aggregation, or alter their interactions with other cellular components. The specificity of ZDHHCjäsenet for their target proteins is thought to be determined by various factors, including the presence of specific recognition motifs on the target proteins and the cellular localization of the ZDHHC enzyme itself.

Dysregulation of ZDHHCjäsenet activity has been implicated in a variety of cellular processes and diseases. They are involved in neuronal development and function, immune responses, and signal transduction pathways. Aberrant palmitoylation due to mutations or altered expression of ZDHHC enzymes has been linked to neurological disorders, cancer, and cardiovascular diseases. Research into ZDHHCjäsenet continues to uncover their diverse roles in cellular biology and their potential as therapeutic targets.