Weefselsterfte

Weefselsterfte, also known as tissue necrosis, refers to the death of cells or entire tissue units within the body. This process can result from various causes, including insufficient blood supply (ischemia), infection, chemical exposure, trauma, or certain medical conditions. It typically involves the loss of cellular integrity and function, leading to tissue breakdown and, if untreated, potential complications such as infection or systemic illness.

The types of weefselsterfte vary based on the underlying cause and affected tissue. Ischemic necrosis occurs when blood flow is obstructed, often seen in conditions like arteriosclerosis or embolism. Infectious necrosis can arise from bacterial, viral, or fungal invasions, causing rapid tissue destruction. Chemical burns, radiation therapy, or exposure to toxins can also induce necrosis by damaging cellular structures directly.

Clinically, tissue necrosis may present as discolored, foul-smelling tissues, often with signs of inflammation or infection. Diagnosis typically involves physical examination, imaging studies, and sometimes tissue biopsies to confirm the extent and nature of tissue death.

Treatment aims to remove necrotic tissue, control infection, and restore blood flow when possible. This may involve surgical debridement, antibiotics, or vascular interventions. In severe cases, amputation or reconstructive procedures might be necessary. Prevention focuses on managing underlying risk factors, such as controlling blood sugar in diabetics or avoiding exposure to harmful chemicals.

Understanding weefselsterfte is crucial in various medical fields, including surgery, dermatology, and wound management, as early intervention can significantly influence patient outcomes and recovery.