Vesikelrecylcling
Vesikelrecylcling is the set of cellular processes by which membrane-bound vesicles and their components are retrieved, reassembled, and reused after vesicular trafficking events. In eukaryotic cells, vesicles bud from donor membranes, carry cargo to target membranes, and must be replenished to maintain membrane area, composition, and the vesicle pool needed for ongoing transport. Vesikelrecylcling encompasses endocytic retrieval of membrane from the plasma membrane and the subsequent restoration of vesicle populations, as well as the recycling of secretory and synaptic vesicles after fusion.
A major feature of vesikelrecylcling is the routing of endocytosed membranes and cargo through early endosomes
Molecularly, vesikelrecylcling relies on regulated membrane scission and fusion. Dynamin mediates vesicle scission; clathrin and adaptor
Vesikelrecylcling is essential for membrane homeostasis, receptor resensitization, synaptic transmission, and secretory cell function. Disruptions in