VEGFbased
VEGFbased refers to approaches that exploit vascular endothelial growth factor (VEGF) signaling to influence angiogenesis. VEGF proteins stimulate the growth and permeability of blood vessels and play key roles in development, wound healing, and pathological neovascularization.
VEGF-A is the principal ligand in most angiogenic processes, acting mainly through receptors VEGFR-1 and VEGFR-2
Therapeutic uses of VEGF-based strategies span pro-angiogenic and anti-angiogenic aims. Pro-angiogenic approaches deliver VEGF protein, gene
Delivery methods include protein injections, gene delivery, and biomaterial systems; safety considerations include dose control and
Ongoing research seeks more precise targeting and safer delivery to unlock broader regenerative and disease-modifying potential