VEGFA
VEGFA, or vascular endothelial growth factor A, is a secreted glycoprotein that stimulates angiogenesis and vasculogenesis. It is a key mediator of blood vessel formation during development and in adult tissue remodeling, influencing endothelial cell proliferation, migration, and survival, as well as vascular permeability.
VEGFA is encoded by the VEGFA gene on chromosome 6p21.1. The protein forms homodimers and is secreted
Signaling through VEGF receptors activates multiple pathways, including PI3K-AKT, PLCγ-PKC, and RAS-RAF-MEK-ERK, leading to endothelial proliferation,
Clinical relevance includes pathologic VEGFA upregulation in tumor angiogenesis and ocular neovascular diseases, such as age-related