Transfluvalinate

Transfluvalinate is the trans isomer of fluvalinate, a synthetic pyrethroid insecticide/acaricide used primarily in beekeeping to control Varroa destructor mites in honey bee colonies. Like other pyrethroids, fluvalinate acts on the nervous system of insects by prolonging the opening of voltage-gated sodium channels, leading to paralysis and death.

In commercial use, fluvalinate formulations typically contain a mixture of cis and trans isomers, with transfluvalinate contributing to the product’s activity. Transfluvalinate is applied in beekeeping as impregnated strips placed inside hives, usually between brood frames. The treatment aims to reduce Varroa mite populations while limiting residues in hive products. Regulations in different countries govern the proper use, withholding periods for honey, and restrictions on where and when the product can be applied.

Residues and safety considerations: Fluvalinate compounds are lipophilic and can persist in beeswax and stored comb, potentially leading to residues in honey, wax, and other hive products. Acute toxicity to humans is low, but handling guidelines and label directions are important to minimize exposure. Environmental and non-target effects are also considerations, particularly with repeated use.

Resistance and management: Varroa mites can develop resistance to fluvalinate with repeated or improper use. Integrated pest management approaches, including rotating miticides and combining cultural controls, are recommended to maintain effectiveness and reduce residue concerns.

Regulatory status: Fluvalinate-based products are registered in many regions for Varroa control, under various brand names. Local regulations determine specific approvals, usage instructions, and residue limits for honey and wax.