SLIT3

SLIT3, also known as slit homolog 3 or slit homolog 3 gene, encodes a protein that belongs to the SLIT family of guidance cues involved in nervous system development. The SLIT proteins are secreted glycoproteins that play crucial roles in axon guidance, neuronal migration, and tissue patterning during embryogenesis.

The SLIT3 gene is located on chromosome 5q34 in humans and consists of multiple exons that encode a protein characterized by leucine-rich repeat (LRR) domains, epidermal growth factor (EGF)-like domains, and a C-terminal cysteine-rich region. These structural features are essential for its interaction with ROBO (Roundabout) receptors, which mediate its guidance functions.

SLIT3 has been implicated in various biological processes, including the regulation of angiogenesis, organ development, and cell migration. Its role in the nervous system involves repulsive signaling that helps direct axonal paths and neuronal positioning. Additionally, SLIT3 has been studied in the context of cancer, where it may influence tumor progression and metastasis through its effects on cell migration and angiogenesis.

Research into SLIT3 is ongoing to elucidate its full range of functions and mechanisms. Alterations or dysregulation of SLIT3 expression have been associated with developmental disorders and diseases such as cancer, highlighting its significance in normal physiology and pathology.

Overall, SLIT3 is a key molecular player in developmental signaling pathways, especially within the nervous and vascular systems, contributing to proper tissue formation and function.