SLC30ZnT
SLC30ZnT, commonly referred to as the ZnT family, denotes the zinc transporters encoded by the SLC30A gene family (SLC30A1 through SLC30A10). These proteins move Zn2+ from the cytosol into intracellular compartments such as the Golgi apparatus and secretory vesicles, or, in some cases, across the plasma membrane to the outside of the cell. In this way, ZnTs contribute to cellular zinc homeostasis and to zinc-dependent enzymatic and signaling processes. The family exhibits diverse tissue distribution and subcellular localization, enabling specialized roles in different cell types.
Notable members include ZnT1 (SLC30A1), typically located at the plasma membrane where it participates in zinc
Structural and mechanistic notes are common across the family: most ZnTs are predicted to have six transmembrane
Clinically, variants in SLC30A genes have been linked to disturbances in zinc homeostasis. In particular, SLC30A8