Polyoliosa
Polyoliosa is a term used in medical literature to describe a proposed spectrum of disorders involving dysregulation of the polyol pathway, the metabolic route that bridges glucose to sugar alcohols such as sorbitol. The term is not standardized and its usage is limited to a small number of theoretical discussions and case reports. It aims to capture conditions with abnormal accumulation of polyols in tissues.
Pathophysiology centers on the polyol pathway. Under normal conditions, aldose reductase reduces glucose to sorbitol, which
Clinical features are multisystemic and variable. Reported manifestations include progressive peripheral neuropathy, cataracts, nephropathy, and autonomic
Diagnosis is not standardized. It is typically made by exclusion and supported by laboratory profiling of polyol
Management emphasizes control of underlying metabolic risk factors; no disease-specific therapy is established. Experimental approaches have
Polyoliosa remains a niche term and is not included in major diagnostic classifications such as ICD-10/11. Current