Percocet

Percocet is a prescription analgesic that combines oxycodone, an opioid receptor agonist, with acetaminophen (paracetamol). It is available in immediate-release tablets and is used to treat moderate to severe pain when a single-agent analgesic is insufficient.

Mechanism of action: Oxycodone binds to mu-opioid receptors in the central nervous system to alter the perception and emotional response to pain. Acetaminophen contributes to pain relief and fever reduction and may enhance the analgesic effect when used with opioids.

Common side effects include drowsiness, dizziness, nausea, vomiting, constipation, and dry mouth. Serious risks include respiratory depression, hypotension, and, with high acetaminophen exposure, liver injury. Combining with alcohol or other hepatotoxic agents increases liver risk. The medication carries a risk of dependence, misuse, and withdrawal symptoms upon discontinuation, particularly with long-term use.

Contraindications include known hypersensitivity to oxycodone or acetaminophen, severe respiratory conditions, acute or severe asthma, or conditions predisposing to brain edema. Caution is advised in liver disease, kidney disease, pregnancy, and in the elderly. Interactions: sedatives, alcohol, and other central nervous system depressants can increase drowsiness and respiratory depression; certain drugs can affect oxycodone metabolism via CYP enzymes.

Regulatory status: Percocet is a controlled substance in many countries and is available only by prescription. Because of misuse risk and potential for overdose, it is typically prescribed for short durations with careful monitoring. Safe storage and disposal are advised to prevent accidental ingestion, especially by children.