Patlak
Patlak plot, also known as Patlak graphical analysis, is a graphical method used in dynamic positron emission tomography (PET) to quantify irreversible tracer uptake in tissue. It was introduced by Patlak, Blasberg, and Fenstermacher in 1983 and has since become a standard tool in kinetic analysis of PET data.
The method relies on time-activity curves from tissue Ct(t) and plasma input Cp(t). Under the assumption of
Ki reflects the rate at which tracer is entering tissue and becoming irreversibly trapped. In practice, Patlak
Limitations include deviations from irreversibility, noise amplification at later times, potential metabolite formation confounding Cp(t), and