PPxY
PPxY is a short amino acid sequence motif commonly found in protein interactions within various biological processes. The motif consists of the amino acids proline (P), proline (P), any amino acid (x), and tyrosine (Y), where 'x' represents any residue. This sequence plays a significant role in mediating protein-protein interactions, especially in cellular signaling, trafficking, and structural functions.
The PPxY motif is predominantly recognized by WW domains, which are small protein modules that specifically
In viral biology, the PPxY motif is noted for its role in the lifecycle of some viruses,
From a structural perspective, the PPxY motif often resides in disordered regions of proteins, allowing flexible
Research on PPxY continues to illuminate its diverse roles across biological systems, emphasizing its relevance in