PPADs
PPADS is a synthetic organic molecule used as a pharmacological antagonist of purinergic P2 receptors, particularly the P2X family. It is highly water-soluble due to sulfonate groups and carries multiple negative charges, which reduces membrane permeability and favors interaction with extracellular receptor sites. PPADS is commonly employed in neuroscience and physiology research to block ATP-activated signaling mediated by P2X receptor channels.
In experimental settings, PPADS inhibits ATP-evoked currents through several P2X receptor subtypes, with potency varying by
PPADS was introduced in the literature during the late 20th century as one of the early P2
Safety and handling follow standard laboratory practices for chemical reagents. PPADS should be prepared and used