OSMI1

OSMI1 may refer to more than one biological entity in public databases. The term is used for a human gene symbol as well as for a small-molecule inhibitor commonly written as OSMI-1. Because these are unrelated in function, careful interpretation depends on the context.

OSMI1 as a gene: In genomic resources, OSMI1 is listed as a protein-coding gene in Homo sapiens. The coded protein is not well characterized, and functional details remain limited in the published literature. Available annotations describe OSMI1 as a relatively poorly understood gene with no established disease associations. Comparative genomics has identified potential orthologs in other species, but specific roles in cellular pathways or developmental processes have not been clearly defined. As with many genes with limited study, ongoing research and database curation are needed to clarify its expression patterns, interacting partners, and physiological significance.

OSMI-1 as a chemical inhibitor: OSMI-1 is a small-molecule inhibitor used in cell biology to modulate O-GlcNAc transferase (OGT) activity. It is employed as a research tool to reduce global O-GlcNAcylation and to probe the functions of O-GlcNAcylation in signaling, metabolism, and stress responses. OSMI-1 is described as cell-permeable and useful for in vitro and cellular assays; it is not approved for clinical use. As with many chemical probes, researchers exercise caution regarding specificity and potential off-target effects, and results are typically complemented with additional methods to confirm OGT-related phenotypes.