Neoandrographolide

Neoandrographolide is a labdane-type diterpene glycoside isolated from Andrographis paniculata, a plant commonly used in traditional medicine and known as kalmegh. It is closely related to andrographolide, sharing the diterpene lactone core but differing by the presence of a glycosidic moiety, which makes neoandrographolide a glycoside of the diterpene scaffold. The compound is one of the major diterpenoids reported from A. paniculata and can be found in various plant parts, often alongside andrographolide.

Occurrence and use in research: Neoandrographolide has been identified in extracts of Andrographis paniculata and is used as a chemical marker in quality control of kalmegh preparations. It has been the subject of phytochemical and pharmacological studies aiming to understand its contribution to the plant’s bioactivity.

Pharmacology and safety: In vitro and some in vivo studies have explored anti-inflammatory, antiviral, and immunomodulatory activities for neoandrographolide, with effects often linked to modulation of inflammatory signaling pathways and cellular immune responses. However, the evidence is preliminary, and there is no established clinical use or regulatory approval for neoandrographolide. As with other plant-derived diterpenoids, careful consideration of dosage, standardization, and safety is important in research contexts.

See also: Andrographolide, Kalmegh.