NDRG
NDRG refers to the NDRG (N-myc downstream-regulated gene) family of proteins, a group of evolutionarily conserved proteins involved in various cellular processes. The family consists of four members: NDRG1, NDRG2, NDRG3, and NDRG4, each encoded by distinct genes located on different chromosomes. These proteins play roles in cell growth, differentiation, stress responses, and apoptosis, with their expression often regulated in response to cellular signals.
NDRG1, the most studied member, is frequently downregulated in cancer cells and has been linked to tumor
NDRG2, NDRG3, and NDRG4 are less characterized but share some functional similarities with NDRG1. NDRG2, for
The NDRG family proteins are characterized by a conserved NDR domain, which mediates their interactions with