McsBMcsA
McsBMcsA refers to a two-protein regulatory system found in several Gram-positive bacteria, most prominently studied in Bacillus subtilis. The complex coordinates protein quality control under stress by coupling proteolysis to phosphorylation signals. It functions at the interface of protein tagging and targeted degradation, helping cells remove damaged or misfolded proteins during conditions such as heat shock or oxidative stress.
The core components are McsB, an ATP-dependent protein arginine kinase, and McsA, a small regulatory partner.
Regulation of the system is linked to the cellular environment. McsB activity is influenced by the redox
Distribution and significance vary among species, but the McsB–McsA module generally serves as a rapid, phosphorylation-based