MTAP
MTAP, an abbreviation for Methylthioadenosine Phosphorylase, is an enzyme involved in the purine salvage pathway, essential for nucleotide metabolism in various organisms, including humans. This enzyme is responsible for catalyzing the breakdown of methylthioadenosine (MTA) into adenine and 5-methylthioribose-1-phosphate, allowing the reuse of adenine in nucleotide synthesis and maintaining cellular metabolic balance.
In humans, MTAP is located on chromosome 9p21, a region frequently deleted in various cancers, including gliomas,
The enzyme is a homotrimer and belongs to the purine phosphorylase family, characterized by its ability to
Research on MTAP continues to explore its functions in normal physiology and disease states. Therapeutic strategies
Overall, MTAP plays a critical role in cellular metabolism, and its disruption has significant implications in