MCRn
MCRn, also known as Melanocortin 4 Receptor, is a G protein-coupled receptor that plays a crucial role in regulating energy balance, appetite, and sexual behavior. It is primarily expressed in the brain, particularly in the hypothalamus, a region of the brain responsible for controlling numerous bodily functions including metabolism and reproduction.
The MCRn receptor is activated by a group of peptide hormones called melanocortins, which are derived from
Mutations in the gene encoding MCRn are a significant cause of monogenic obesity in humans. Individuals with
Beyond its role in appetite regulation, MCRn is also involved in other physiological processes. Research suggests