Lossidoperossidazione

Lossidoperossidazione is not a standard term in chemistry or biochemistry. It appears to be a neologism or a possible misspelling that combines elements related to oxidation and peroxide formation. In scientific writing, discussions of lipid oxidation typically use the term lipid peroxidation (perossidazione dei lipidi in italiano). When lossidoperossidazione is encountered, its meaning should be defined by the author to avoid ambiguity.

If interpreted as lipid peroxidation, lossidoperossidazione would refer to oxidative modification of lipids, especially polyunsaturated fatty acids in biological membranes. The process generally starts with initiation by reactive oxygen species, such as hydroxyl radicals, abstracting a hydrogen atom from a fatty acid to form lipid radicals. Propagation then produces lipid peroxyl radicals and lipid hydroperoxides, which can break down into reactive aldehydes and other secondary products. Antioxidants (for example, vitamin E) and enzymatic systems (such as glutathione peroxidase) can limit this chain reaction, while metals and high oxidative stress promote it.

Biological significance and measurement are central to the topic. Lipid peroxidation is linked to aging and various diseases, including atherosclerosis and neurodegeneration, due to membrane damage and formation of reactive aldehydes like malondialdehyde and 4-hydroxynonenal. Common measurement approaches include assays for malondialdehyde (MDA), lipid hydroperoxides, and thiobarbituric acid reactive substances (TBARS). Researchers often report both primary products (lipid hydroperoxides) and secondary products (aldehydes) to characterize the extent of peroxidation.

In practice, lossidoperossidazione should be defined clearly when used. The established term in Italian literature remains perossidazione lipidica or ossidazione lipidica.