Levofloxacin
Levofloxacin is a fluoroquinolone antibiotic used to treat a variety of infections caused by susceptible bacteria. It is the levo isomer of ofloxacin and has activity against many Gram-negative bacteria and some Gram-positive organisms.
The mechanism of action involves inhibition of bacterial DNA gyrase and topoisomerase IV, enzymes essential for
Common indications include community-acquired pneumonia, acute bacterial sinusitis, chronic bronchitis exacerbations, urinary tract infections (including pyelonephritis),
Levofloxacin is available in oral and intravenous forms, with high oral bioavailability that approaches IV exposure,
Safety considerations include common adverse effects such as nausea, diarrhea, and headache. Serious risks, which have
Drug interactions include reduced absorption with concurrent multivalent cations (e.g., antacids, iron, calcium, sucralfate); separate dosing