sucralfate

Sucralfate is a medication used to treat and prevent ulcers of the stomach and duodenum and to manage symptoms of erosive gastritis and certain forms of esophagitis. It is an aluminum hydroxide complex of sucrose sulfate. In an acidic gastric environment, it forms a viscous, adherent gel that binds to ulcer sites and exposed mucosa, creating a protective barrier against acid, pepsin, and bile and potentially promoting healing.

Pharmacokinetics and administration: most of the dose remains in the gastrointestinal tract and is excreted in feces, with minimal systemic absorption. It is usually taken on an empty stomach and can be formulated as tablets or a liquid suspension.

Dosing and indications: in adults, a common regimen is 1 gram taken four times daily (every 6 hours), before meals and at bedtime, for up to about 8 weeks. Maintenance therapy may use lower daily doses. Pediatric dosing is weight-based and varies; guidance from a clinician should be followed.

Interactions and cautions: sucralfate can interfere with the absorption of other medications. It should be taken at least 2 hours apart from medicines such as fluoroquinolone and tetracycline antibiotics, as well as other agents that require good gastric absorption. It may also affect iron, digoxin, and other drugs, so timing should be coordinated with a healthcare provider. Common side effects include constipation, nausea, and dry mouth. Aluminum-containing preparations carry a risk of aluminum accumulation in people with significant renal impairment; use with caution in renal disease. Data on safety in pregnancy and lactation are limited, and treatment should be guided by clinical need. Brand names include Carafate, among others.