Isolaators
Isolaators are enclosed devices that create a controlled environment to protect products from contamination and to shield operators from hazardous materials. They are sealed or semi-sealed chambers that filter the internal atmosphere and can maintain positive or negative pressure relative to the surrounding room. The concept is widely used in aseptic processing, handling of toxic or sensitive materials, and processes requiring strict contamination control.
Isolaators come in several configurations, including glovebox isolators with integrated glove ports for manipulation, and closed
Key components typically include high-efficiency particulate air (HEPA) or ULPA filters, controlled airflows, glove ports, an
Applications span pharmaceutical manufacturing and aseptic compounding, cell culture and virology work, electronic and mechanical assembly
Maintenance and validation are essential: routine leak testing, filter integrity tests, and formal IQ/OQ/PQ commissioning ensure