HSSPME
HSSPME, or headspace solid-phase microextraction, is a solvent-free sample preparation technique used to extract volatile and semi-volatile compounds from the headspace above a sample. In HSSPME, a fiber coated with a sorbent material is exposed to the headspace, allowing analytes to partition onto the coating. After sampling, the fiber is removed and thermally desorbed in the inlet of a gas chromatograph, often coupled to a mass spectrometer, where the analytes are separated and detected.
The technique relies on the partitioning of compounds between the sample matrix, the headspace vapor, and the
Typical method parameters include fiber coating and exposure time, extraction temperature, and whether salt is added