GntRDNA
GntRDNA refers to the DNA sequences that are recognized and bound by proteins of the GntR family of transcriptional regulators. The GntR family is one of the largest families of transcription factors found in bacteria, and members of this family typically regulate genes involved in nutrient utilization, secondary metabolism, and stress responses. GntRDNA motifs are short conserved sequences located in the promoter regions of target genes, wherein the GntR proteins can act as activators or repressors depending on their DNA-binding domain and effector ligands.
The GntR family was first characterized in the 1970s with studies of the Galactose operon in Escherichia
Structurally, GntR proteins possess a winged helix-turn-helix domain that directly contacts the DNA duplex, flanked by
GntRDNA elements are used in synthetic biology to construct genetically engineered bacterial strains with tunable gene
The study of GntRDNA remains active, with ongoing research focusing on the mechanistic basis of cofactor-mediated