GntR
GntR is a family of bacterial transcriptional regulators that typically function as homodimeric proteins controlling genes involved in diverse metabolic processes. Members of this family are characterized by a conserved N‑terminal helix‑turn‑helix DNA‑binding domain that recognizes operator sequences in promoter regions, and a variable C‑terminal domain that mediates effector binding and oligomerization. The name “GntR” originally derived from the transcription factor GntR in *Bacillus subtilis*, which regulates the gluconate utilization operon, but the family has since expanded to include regulators of nitrate assimilation, amino acid catabolism, virulence factor expression, and other cellular functions.
Phylogenetically, GntR proteins are divided into several subfamilies (e.g., I, II, III, IV) based on sequence homology
Functionally, GntR regulators typically act as repressors or activators by binding DNA in the presence or absence