Febrissanasta

Febrissanasta, also known as "fever of the saints," is a rare and often misunderstood medical condition characterized by a high fever that occurs in response to the consumption of certain foods, particularly those containing tyramine. This condition is more commonly observed in individuals with certain genetic predispositions, such as those with a deficiency in the enzyme monoamine oxidase A (MAOA), which is responsible for breaking down tyramine.

The term "febrissanasta" is derived from the Greek words "febris," meaning fever, and "sanasta," meaning "to be cured." The condition was first described in the medical literature in the early 20th century, and its exact prevalence and incidence are not well-documented due to its rarity and the fact that it can be easily misdiagnosed as other, more common conditions such as food poisoning or infectious diseases.

The primary trigger for febrissanasta is the consumption of foods rich in tyramine, such as aged cheeses, fermented meats, and certain types of fish. When these foods are ingested, the tyramine is absorbed into the bloodstream and, in individuals with MAOA deficiency, is not properly metabolized. This leads to a rapid increase in blood pressure and a subsequent rise in body temperature, resulting in a high fever.

Treatment for febrissanasta typically involves avoiding the consumption of tyramine-rich foods and, in some cases, the use of medications to lower blood pressure and reduce fever. In severe cases, hospitalization may be necessary to manage symptoms and prevent complications. The condition is generally considered benign and does not cause long-term health issues, but it can be quite uncomfortable for those who experience it.