ExdHth
ExdHth refers to the functional transcriptional cofactor complex formed by the Drosophila proteins Extradenticle (Exd) and Homothorax (Hth). This heterodimer acts as a cofactor for Hox proteins, expanding their DNA-binding specificity and enabling proper patterning along the proximal–distal axis during embryogenesis and in imaginal discs.
Exd and Hth are both TALE-class homeobox factors that interact to form the Exd/Hth complex, which can
The Exd/Hth module is evolutionarily conserved as a cofactor system; in vertebrates, the homologous proteins Meis
Functional roles of ExdHth include regulation of proximal–distal identity in limbs and other structures, contributing to
In summary, ExdHth is a key transcriptional cofactor complex in Drosophila that partners with Hox proteins