EndDiastolische

EndDiastolische is a term used in physiology and cardiology to describe the state at the end of diastole, the phase of the cardiac cycle when the ventricles have completed filling and are ready to begin systole. Diastole follows systole and comprises rapid filling, diastasis, and atrial systole. The end-diastolic moment occurs immediately before the onset of ventricular contraction (isovolumetric contraction) and is commonly associated with the end-diastolic volume (EDV).

In practice, EndDiastolische concepts are most often discussed in relation to the left ventricle, though they can apply to the right ventricle as well. The end-diastolic state reflects ventricular preload and is a key determinant of stroke volume through the Frank–Starling mechanism: higher EDV generally increases contractile force and output, up to physiological limits. End-diastolic pressure (LVEDP or RVEDP) provides information about filling pressures and ventricular compliance.

Measurement and assessment: Enddiastolische metrics are measured by imaging and, when necessary, invasive methods. Left ventricular end-diastolic volume (LVEDV) and end-diastolic diameter are commonly assessed by echocardiography or cardiac MRI. Invasive ventriculography or catheterization can provide precise LVEDP. Doppler and tissue Doppler studies contribute to evaluating diastolic function, including filling patterns (E/A ratio, deceleration time, and myocardial velocities) that influence interpretation of end-diastolic status.

Clinical relevance: Abnormally high end-diastolic volumes or pressures can indicate volume overload, dilated cardiomyopathy, or heart failure with reduced ejection fraction, while low end-diastolic values may reflect hypovolemia or reduced preload. Understanding EndDiastolische states aids in diagnosing cardiac conditions and guiding management focused on preload and diastolic function.