Diaminoxidáz

Diaminoxidáz (DAO) is an enzyme that plays a crucial role in the metabolic breakdown of biogenic amines, most notably histamine. It is primarily found in the intestinal lining, liver, and kidneys. DAO functions by catalyzing the oxidative deamination of primary amines, converting them into their corresponding aldehydes and ammonia. This enzymatic activity is essential for regulating the levels of histamine and other vasoactive amines that are ingested through diet or produced by the body.

Histamine, in particular, is a neurotransmitter and immune modulator that is present in many foods like aged cheeses, fermented products, and certain fruits. When DAO activity is insufficient, histamine can accumulate in the body, leading to a condition known as histamine intolerance. Symptoms associated with histamine intolerance can be varied and may include digestive issues, headaches, skin rashes, and respiratory problems. Genetic factors and certain medications can also influence DAO activity. The measurement of DAO levels in the blood can be used as a diagnostic tool for assessing potential histamine intolerance.