Deferipron
Deferiprone, sometimes spelled deferipron in less common sources, is an oral iron chelating agent used to treat systemic iron overload in people who receive regular blood transfusions. It is particularly applied in conditions such as beta-thalassemia major and other anemias associated with transfusional iron loading, including situations where other chelators are not suitable or accessible. It is commonly used as part of a chelation strategy when deferoxamine is not feasible and may be used alone or in combination with other therapies depending on the clinical scenario and regional guidelines.
Deferiprone binds ferric iron (Fe3+) to form soluble complexes that are excreted from the body, primarily via
Deferiprone is taken by mouth in divided doses, with a total daily dose typically around 75 mg/kg,
A major safety consideration is the risk of neutropenia and agranulocytosis, which requires regular blood monitoring,
Regulatory status and monitoring
Deferiprone is approved in many regions for transfusional iron overload in patients who cannot use other chelation