DNMTd
DNMTd refers to the conserved catalytic domain of DNA methyltransferases, a core region responsible for the transfer of a methyl group to cytosine residues in DNA. The term is often used to describe the catalytic core shared by cytosine-5 DNA methyltransferases (C5-DNMTs) found across bacteria, archaea, and eukaryotes, and it may be discussed separately from the regulatory or targeting regions that accompany the domain in full-length enzymes. The DNMTd alone is sufficient for the chemical step of methylation, while additional domains and motifs guide substrate recognition and enzyme localization.
The DNMTd is the enzymatic heart of DNA methyltransferases. It binds S-adenosyl-L-methionine (SAM) as the methyl
DNMTd-containing enzymes are found in a wide range of organisms. In vertebrates, full-length DNMTs (such as DNMT1
DNA methylation by DNMTs is a key epigenetic mark involved in gene regulation, development, genomic stability,
DNMTd is commonly referenced in discussions of the catalytic core rather than as a standalone gene. For