DAB2IP
DAB2IP stands for DAB2 interacting protein and refers to a cytoplasmic signaling protein encoded by the DAB2IP gene on chromosome 9q33-34. It is a Ras-GAP–like protein that contains multiple conserved domains, including a C2 domain, a PH domain, and a Ras-GAP–related domain, enabling it to modulate signaling pathways and act as a scaffolding protein in various cellular processes.
Functionally, DAB2IP serves as a tumor suppressor by negatively regulating Ras signaling and modulating pathways that
Regulation of DAB2IP is frequently disrupted in cancer. The gene is commonly downregulated or silenced by promoter
Clinical and research interest in DAB2IP includes its potential use as a prognostic biomarker based on methylation