RasGAPlike
RasGAPlike refers to a class of proteins that resemble Ras GTPase-activating proteins (GAPs) in their domain architecture or catalytic capability. These proteins typically contain a RasGAP catalytic domain or related sequence motifs and are involved in regulating Ras family GTPases, which act as molecular switches in cell signaling. RasGAPlike proteins can function as genuine GAPs that accelerate GTP hydrolysis on Ras, turning off signaling, or they may possess degenerate or partial GAP domains that influence signaling through alternative mechanisms or interactions.
Structurally, RasGAPlike proteins often feature a central RasGAP domain and may carry additional regulatory or targeting
RasGAPlike proteins are distributed across eukaryotes and show considerable diversity in domain organization and function. Some
In biology and medicine, RasGAPlike proteins are studied for their roles in controlling signaling persistence and