CpGsites
CpG sites are regions of DNA where a cytosine nucleotide is followed by a guanine nucleotide in the linear sequence, connected by a phosphate bond. The term “CpG” reflects the dinucleotide on the same strand, and such sites are widespread throughout the genome, with particular clustering in certain regions.
In many organisms, including humans, the cytosine within CpG dinucleotides can be modified by methylation to
CpG islands are genomic regions with a high density of CpG sites and a relatively high GC
Alterations in CpG methylation patterns are associated with development, aging, imprinting disorders, and various diseases, including