singlebase

Singlebase is a term encountered across genetics, biotechnology, and information technology. It is not a single, formal entity with a canonical definition; rather, it functions as a label for concepts and products that center on an individual nucleotide position in DNA.

In genomics, single-base variation refers to changes at a single nucleotide, including single-nucleotide polymorphisms (SNPs) and other SNVs. Modern sequencing technologies provide single-base resolution, enabling precise identification and characterization of substitutions at individual bases across genomes.

In biotechnology, "single-base editing" describes techniques that change one DNA base into another at a targeted locus without introducing double-strand breaks. Base editing approaches include cytosine base editors, which convert C to T, and adenine base editors, which convert A to G. These methods are designed to minimize unintended edits and are under active development for research and therapeutic applications.

In commerce and software, the name Singlebase is used by several companies and products related to sequencing, variant analysis, or genome editing services. No single company currently holds universal recognition of the term, though multiple startups may use similar branding for their DNA-focused offerings.

Related terms include single-nucleotide polymorphism (SNP), single-nucleotide variant (SNV), and base editing.