CREBns

CREBns, also known as Cyclic AMP response element-binding protein, not-small, are a group of transcriptional co-activators that play a crucial role in various cellular processes, including learning, memory, and stress response. They are part of the larger CREB family of transcription factors, which are involved in regulating gene expression. CREBns are characterized by their ability to bind to cyclic AMP response elements (CREs) in the promoter regions of target genes. This binding event often leads to the recruitment of other proteins, forming a complex that either activates or represses gene transcription. The activity of CREBns is tightly regulated through post-translational modifications, such as phosphorylation, acetylation, and ubiquitination, which can alter their DNA-binding affinity, protein-protein interactions, and subcellular localization. Dysregulation of CREBns has been implicated in a number of neurological disorders, including Alzheimer's disease, Parkinson's disease, and depression, highlighting their importance in maintaining neuronal function and cognitive health. Research into CREBns continues to explore their diverse roles in cellular signaling and their potential as therapeutic targets for a range of diseases.