Brimonidine
Brimonidine is a medication used in both ophthalmology and dermatology. In ophthalmology, it is a selective alpha-2 adrenergic receptor agonist that lowers intraocular pressure by decreasing aqueous humor production and, to a lesser extent, increasing uveoscleral outflow. It is indicated for open-angle glaucoma and ocular hypertension and is available as an eye drop in several concentrations, commonly 0.1%, 0.15%, or 0.2% brimonidine tartrate, depending on the market. Fixed-dose combinations include Combigan, which combines brimonidine tartrate 0.2% with timolol maleate 0.5%, and Simbrinza, which pairs brimonidine tartrate with brinzolamide.
In dermatology, brimonidine tartrate 0.5% gel is used to treat facial erythema of rosacea under brand names
Mechanism and pharmacology: Brimonidine is a selective agonist of alpha-2 adrenergic receptors. In the eye, this
Side effects: Common ocular adverse effects include conjunctival hyperemia, dry eye, ocular pruritus, and blurred vision.
Storage and handling: Use as prescribed and store at room temperature; discard after opening as directed by