Arp23dependent

Arp23-dependent refers to biological processes, regulatory events, or phenotypes that require the action or presence of the actin-related protein Arp23. Arp23 is an actin-related protein that participates in multiple multi-subunit complexes that regulate chromatin structure and cytoskeletal organization. Because of its integration into these complexes, Arp23-dependent pathways commonly involve chromatin remodeling and actin-based dynamics, affecting nucleosome positioning, histone exchange, and transcriptional regulation as well as cytoskeletal organization within the nucleus or cytoplasm.

In experimental systems, Arp23 dependency is often demonstrated by genetic or biochemical disruption of Arp23 resulting in reduced chromatin accessibility, altered gene expression profiles, or defects in cell morphology and motility. The precise role of Arp23 can vary by organism, but orthologous proteins have been identified across diverse eukaryotes, supporting a conserved function in linking actin-related activity to chromatin or cytoskeletal processes.

Terminology: Researchers may describe certain phenotypes as Arp23-dependent when the observed effect disappears or is significantly diminished in Arp23 mutants or knockdowns, indicating reliance on Arp23-containing complexes. Investigations aim to map the interactions between Arp23 and other complex subunits, define its contribution to nucleosome dynamics, and clarify how Arp23 coordinates structural changes with gene expression or cell movement.